Detecting Parkinson’s by smell

Are we facing a Parkinson’s pandemic
30th October 2023
Nutritious meals
27th November 2023

Detecting Parkinson’s by smell

Detecting Parkinson’s by smell

Woman who smelled Parkinson’s on husband helps scientists

By Elizabeth Quigley
BBC Scotland news

A Scottish woman who found she could detect Parkinson’s through smell has inspired scientists to develop a swab test that could be used to diagnose it.

Researchers in Manchester UK have created a new method which they say can detect the disease in three minutes.

Further study will be required to validate the findings before they can develop a diagnostic test that could be used in clinics or by GPs. Their work was inspired by Joy Milne, a retired nurse from Perth.

Joy, 72, knew her husband Les had Parkinson’s more than 12 years before he was diagnosed when she identified a change in the way he smelled.

“He had this musty rather unpleasant smell especially round his shoulders and the back of his neck and his skin had definitely changed,” she said.

She only linked the odour to the disease after Les was diagnosed and they met people at a Parkinson’s UK support group who had the same distinctive smell. Les died in June 2015.

Now a team in the University of Manchester, working with Joy, has developed a simple skin-swab test which they claim is 95 percent accurate under laboratory conditions when it comes to telling whether people have Parkinson’s.

The researchers analysed sebum – the oily substance on skin – which was collected by using a cotton swab on patients’ backs, an area where it is less often washed away. Using mass spectrometry, they compared 79 people with Parkinson’s with a healthy control group of 71 people.

The research found more than 4,000 unique compounds in the samples, of which 500 were different between people with Parkinson’s and the control group.

The study is published in the Journal of the American Chemical Society.

Prof Perdita Barran, who led the research, said there was not currently a chemical test for Parkinson’s disease and many thousands of people were on waiting lists for a neurological consultation. She said developing a confirmatory test that could be used by a GP would be “transformative”.

“At the moment we have developed it in a research lab and we are now working with colleagues in hospital analytical labs to transfer our test to them so that it can work within a National Health Service environment,” she said.

“We are hoping within two years to be able to start to test people in the Manchester area.”

The scientists now need to validate their findings in a clinical lab before it can be used for patients.

James Jopling, the Scotland director of Parkinson’s UK, said the discovery could make a real difference to people living with the disease.

“Currently with no definitive test people have to wait months or years to be diagnosed so the fact that you could get the treatment and support you need and that researchers could begin new treatments is incredibly important,” he said.

Joy knows what an earlier diagnosis would have meant for her and her family.

“We would have spent more time with family,” she said. “We would have travelled more. If we had known earlier it might have explained the mood swings and depression.”

The night before her husband died, he made her promise to investigate her sense of smell.

According to Joy, he said: “You must do this because it will make a difference.”

She hopes her accidental discovery will do exactly that.